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Druggable Orthosteric and Allosteric Hot Spots to Target Protein-protein Interactions
Drug designing targeting protein-protein interactions is challenging. Because structural elucidation and computational analysis have revealed the importance of hot spot residues in stabilizing these interactions, there have been on-going efforts to develop drugs which bind the hot spots and out-comp...
Gardado en:
| Publicado en: | Curr Pharm Des |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6361532/ https://ncbi.nlm.nih.gov/pubmed/23713780 |
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