How Similar Are Protein Folding and Protein Binding Nuclei? Examination of Vibrational Motions of Energy Hot Spots and Conserved Residues

The underlying physico-chemical principles of the interactions between domains in protein folding are similar to those between protein molecules in binding. Here we show that conserved residues and experimental hot spots at intermolecular binding interfaces overlap residues that vibrate with high fr...

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Bibliographic Details
Main Authors: Haliloglu, Turkan, Keskin, Ozlem, Ma, Buyong, Nussinov, Ruth
Format: Artigo
Language:Inglês
Published: Biophysical Society 2005
Subjects:
Biophysical Theory and Modeling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1305212/
https://ncbi.nlm.nih.gov/pubmed/15596504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.051342
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