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First Structure of a Designed Minor Groove Binding Heterocyclic Cation that Specifically Recognizes Mixed DNA base pair Sequences

The high-resolution NMR structure of the first heterocyclic, non-amide, organic cation that strongly and selectively recognizes mixed AT/GC bp sequences of DNA in a 1:1 complex is described. Compound designs of this type provide essential methods for control of functional, non-genomic DNA sequences...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chemistry
Main Authors: Harika, Narinder K., Germann, Markus W., Wilson, W. David
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360951/
https://ncbi.nlm.nih.gov/pubmed/29044822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201704563
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