The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model

Buruli ulcer (BU) is an emerging infectious disease that causes disfiguring skin ulcers. The causative agent, Mycobacterium ulcerans, secretes toxin called mycolactone that triggers inflammation and immunopathology. Existing treatments are lengthy and consist of drugs developed for tuberculosis. Her...

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Pubblicato in:Nat Commun
Autori principali: Liu, Yang, Gao, Yamin, Liu, Jianxiong, Tan, Yaoju, Liu, Zhiyong, Chhotaray, Chiranjibi, Jiang, Huofeng, Lu, Zhili, Chiwala, Gift, Wang, Shuai, Makafe, Gaelle, Islam, Md Mahmudul, Hameed, H. M. Adnan, Cai, Xingshan, Wang, Changwei, Li, Xinjie, Tan, Shouyong, Zhang, Tianyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355801/
https://ncbi.nlm.nih.gov/pubmed/30705268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08464-y
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