An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia

Energy stress, such as ischemia, induces mitochondrial damage and death in the heart. Degradation of damaged mitochondria by mitophagy is essential for the maintenance of healthy mitochondria and survival. Here, we show that mitophagy during myocardial ischemia was mediated predominantly through aut...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Saito, Toshiro, Nah, Jihoon, Oka, Shin-ichi, Mukai, Risa, Monden, Yoshiya, Maejima, Yasuhiro, Ikeda, Yoshiyuki, Sciarretta, Sebastiano, Liu, Tong, Li, Hong, Baljinnyam, Erdene, Fraidenraich, Diego, Fritzky, Luke, Zhai, Peiyong, Ichinose, Shizuko, Isobe, Mitsuaki, Hsu, Chiao-Po, Kundu, Mondira, Sadoshima, Junichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355232/
https://ncbi.nlm.nih.gov/pubmed/30511961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122035
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