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Structural basis of Ca(2+)-dependent activation and lipid transport by a TMEM16 scramblase
The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients. As a result, phosphatidylserine is exposed to the outer leaflet of membrane, a...
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| 出版年: | eLife |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6355197/ https://ncbi.nlm.nih.gov/pubmed/30648972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43229 |
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