Structural basis of Ca(2+)-dependent activation and lipid transport by a TMEM16 scramblase

The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients. As a result, phosphatidylserine is exposed to the outer leaflet of membrane, a...

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Veröffentlicht in:eLife
Hauptverfasser: Falzone, Maria E, Rheinberger, Jan, Lee, Byoung-Cheol, Peyear, Thasin, Sasset, Linda, Raczkowski, Ashleigh M, Eng, Edward T, Di Lorenzo, Annarita, Andersen, Olaf S, Nimigean, Crina M, Accardi, Alessio
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Structural Biology and Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355197/
https://ncbi.nlm.nih.gov/pubmed/30648972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43229
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