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Structural basis of Ca(2+)-dependent activation and lipid transport by a TMEM16 scramblase
The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients. As a result, phosphatidylserine is exposed to the outer leaflet of membrane, a...
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| Publicado en: | eLife |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6355197/ https://ncbi.nlm.nih.gov/pubmed/30648972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43229 |
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