Diet-induced β-cell insulin resistance results in reversible loss of functional β-cell mass

Although convincing in genetic models, the relevance of β-cell insulin resistance in diet-induced type 2 diabetes (T2DM) remains unclear. Exemplified by diabetes-prone, male, C57B1/6J mice being fed different combinations of Western-style diet, we show that β-cell insulin resistance occurs early dur...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Paschen, Meike, Moede, Tilo, Valladolid-Acebes, Ismael, Leibiger, Barbara, Moruzzi, Noah, Jacob, Stefan, García-Prieto, Concha F., Brismar, Kerstin, Leibiger, Ingo B., Berggren, Per-Olof
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355083/
https://ncbi.nlm.nih.gov/pubmed/29957055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800826R
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