Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4

VEGF signaling via VEGF receptor-2 (VEGFR2) is a major regulator of endothelial cell (EC) functions, including angiogenesis. Although most studies of angiogenesis focus on soluble VEGF signaling, mechanical signaling also plays a critical role. Here, we examined the consequence of disruption of mech...

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Veröffentlicht in:FASEB J
Hauptverfasser: Kanugula, Anantha K., Adapala, Ravi K., Midha, Priya, Cappelli, Holly C., Meszaros, J. Gary, Paruchuri, Sailaja, Chilian, William M., Thodeti, Charles K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355071/
https://ncbi.nlm.nih.gov/pubmed/29957061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800509R
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