Mechanosensitive TRPV4 channels stabilize VE-cadherin junctions to regulate tumor vascular integrity and metastasis

The transient receptor potential vanilloid 4 (TRPV4) channel is a mechanosensor in endothelial cells (EC) that regulates cyclic strain-induced reorientation and flow mediated nitric oxide production. We have recently demonstrated that TRPV4 expression is reduced in tumor EC and tumors grown in TRPV4...

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Gepubliceerd in:Cancer Lett
Hoofdauteurs: Cappelli, Holly C., Kanugula, Anantha K., Adapala, Ravi K., Amin, Vibhatsu, Sharma, Priya, Midha, Priya, Paruchuri, Sailaja, Thodeti, Charles K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6924277/
https://ncbi.nlm.nih.gov/pubmed/30401632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.07.042
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