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TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation

Cardiac fibrosis caused by adverse cardiac remodeling following myocardial infarction can eventually lead to heart failure. Although the role of soluble factors such as TGF-β is well studied in cardiac fibrosis following myocardial injury, the physiological role of mechanotransduction is not fully u...

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Bibliographic Details
Published in:Basic Res Cardiol
Main Authors: Adapala, Ravi K., Kanugula, Anantha K., Paruchuri, Sailaja, Chilian, William M., Thodeti, Charles K.
Format: Artigo
Language:Inglês
Published: 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322630/
https://ncbi.nlm.nih.gov/pubmed/31925567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-020-0775-5
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