Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy

Tumor vessels are characterized by abnormal morphology and hyper-permeability that together cause inefficient delivery of chemotherapeutic agents. Although VEGF has been established as a critical regulator of tumor angiogenesis, the role of mechanical signaling in the regulation of tumor vasculature...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Adapala, Ravi K., Thoppil, Roslin J., Ghosh, Kaustabh, Cappelli, Holly, Dudley, Andrew C., Paruchuri, Sailaja, Keshamouni, Venkateshwar, Klagsbrun, Michael, Meszaros, J. Gary, Chilian, William M., Ingber, Donald E., Thodeti, Charles K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948740/
https://ncbi.nlm.nih.gov/pubmed/25867067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.83
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