Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy

Tumor vessels are characterized by abnormal morphology and hyper-permeability that together cause inefficient delivery of chemotherapeutic agents. Although VEGF has been established as a critical regulator of tumor angiogenesis, the role of mechanical signaling in the regulation of tumor vasculature...

Full description

Saved in:
Bibliographic Details
Published in:Oncogene
Main Authors: Adapala, Ravi K., Thoppil, Roslin J., Ghosh, Kaustabh, Cappelli, Holly, Dudley, Andrew C., Paruchuri, Sailaja, Keshamouni, Venkateshwar, Klagsbrun, Michael, Meszaros, J. Gary, Chilian, William M., Ingber, Donald E., Thodeti, Charles K.
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948740/
https://ncbi.nlm.nih.gov/pubmed/25867067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.83
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items