Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy

Tumor vessels are characterized by abnormal morphology and hyper-permeability that together cause inefficient delivery of chemotherapeutic agents. Although VEGF has been established as a critical regulator of tumor angiogenesis, the role of mechanical signaling in the regulation of tumor vasculature...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Adapala, Ravi K., Thoppil, Roslin J., Ghosh, Kaustabh, Cappelli, Holly, Dudley, Andrew C., Paruchuri, Sailaja, Keshamouni, Venkateshwar, Klagsbrun, Michael, Meszaros, J. Gary, Chilian, William M., Ingber, Donald E., Thodeti, Charles K.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948740/
https://ncbi.nlm.nih.gov/pubmed/25867067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.83
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires