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Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells

BACKGROUND AIMS: Delaying replicative senescence and extending lifespan of human mesenchymal stromal cells (MSCs) may enhance their potential for tissue engineering and cell based therapies. Accumulating evidence suggests that inhibitors of the mTOR signaling pathway, such as rapamycin, constitute p...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Antonioli, Eliane, Torres, Natália, Ferretti, Mario, Piccinato, Carla de Azevedo, Sertie, Andrea Laurato
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354956/
https://ncbi.nlm.nih.gov/pubmed/30703123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204784
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