Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells

BACKGROUND AIMS: Delaying replicative senescence and extending lifespan of human mesenchymal stromal cells (MSCs) may enhance their potential for tissue engineering and cell based therapies. Accumulating evidence suggests that inhibitors of the mTOR signaling pathway, such as rapamycin, constitute p...

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Vydáno v:PLoS One
Hlavní autoři: Antonioli, Eliane, Torres, Natália, Ferretti, Mario, Piccinato, Carla de Azevedo, Sertie, Andrea Laurato
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354956/
https://ncbi.nlm.nih.gov/pubmed/30703123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204784
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