Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells

BACKGROUND AIMS: Delaying replicative senescence and extending lifespan of human mesenchymal stromal cells (MSCs) may enhance their potential for tissue engineering and cell based therapies. Accumulating evidence suggests that inhibitors of the mTOR signaling pathway, such as rapamycin, constitute p...

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Udgivet i:PLoS One
Main Authors: Antonioli, Eliane, Torres, Natália, Ferretti, Mario, Piccinato, Carla de Azevedo, Sertie, Andrea Laurato
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354956/
https://ncbi.nlm.nih.gov/pubmed/30703123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204784
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