High OCT4 and Low p16(INK4A) Expressions Determine In Vitro Lifespan of Mesenchymal Stem Cells

After long-term culture, mesenchymal stem cells alter their biological properties and enter into a state of replicative senescence. Although several classical biomarkers have been used for quantitative assessment of cellular senescence, no hallmark has been proven completely unique to the senescent...

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Bibliographic Details
Published in:Stem Cells Int
Main Authors: Piccinato, Carla A., Sertie, Andrea L., Torres, Natália, Ferretti, Mario, Antonioli, Eliane
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454755/
https://ncbi.nlm.nih.gov/pubmed/26089914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/369828
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