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Recruitment of calcineurin to the T cell receptor positively regulates T cell activation
Calcineurin is a phosphatase whose primary targets in T cells are NFAT transcription factors, and inhibition of calcineurin activity by treatment with cyclosporin A (CsA) or FK506 is a cornerstone of immunosuppressive therapies. Here we show that calcineurin is recruited to the T cell receptor signa...
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| 出版年: | Nat Immunol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6352896/ https://ncbi.nlm.nih.gov/pubmed/27941787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3640 |
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