Calcineurin inhibitors suppress acute graft-versus-host disease via NFAT-independent inhibition of T cell receptor signaling

Inhibitors of calcineurin phosphatase activity (CNIs) such as cyclosporin A (CsA) are widely used to treat tissue transplant rejection and acute graft-versus-host disease (aGVHD), for which inhibition of gene expression dependent on nuclear factor of activated T cells (NFAT) is the mechanistic parad...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Otsuka, Shizuka, Melis, Nicolas, Gaida, Matthias M., Dutta, Debjani, Weigert, Roberto, Ashwell, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159692/
https://ncbi.nlm.nih.gov/pubmed/33822776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI147683
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