Host NLRP6 exacerbates graft-versus-host disease independent of gut microbial composition

Host NOD-like receptor family pyrin domain-containing 6 (NLRP6) regulates innate immune responses and gastrointestinal homeostasis. Its protective role in intestinal colitis and tumorigenesis is dependent on the host microbiome. Host innate immunity and microbial diversity also play a role in the se...

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Published in:Nat Microbiol
Main Authors: Toubai, Tomomi, Fujiwara, Hideaki, Rossi, Corinne, Riwes, Mary, Tamaki, Hiroya, Zajac, Cynthia, Liu, Chen, Mathew, Anna V., Byun, Jaeman, Oravecz-Wilson, Katherine, Matsuda, Ikuo, Sun, Yaping, Peltier, Daniel, Wu, Julia, Chen, Jiachen, Seregin, Sergey, Henig, Israel, Kim, Stephanie, Brabbs, Stuart, Pennathur, Subramaniam, Chen, Grace, Reddy, Pavan
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689241/
https://ncbi.nlm.nih.gov/pubmed/30858572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0373-1
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