Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy

The objective of this study was to identify unknown modulators of Calcineurin (Cn)-NFAT signaling. Measurement of NFAT reporter driven luciferase activity was therefore utilized to screen a human cardiac cDNA-library (~10(7) primary clones) in C2C12 cells through serial dilutions until single clones...

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Publicado en:Sci Rep
Autores principales: Bernt, Alexander, Rangrez, Ashraf Y., Eden, Matthias, Jungmann, Andreas, Katz, Sylvia, Rohr, Claudia, Müller, Oliver J., Katus, Hugo A., Sossalla, Samuel T., Williams, Tatjana, Ritter, Oliver, Frank, Derk, Frey, Norbert
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073337/
https://ncbi.nlm.nih.gov/pubmed/27767176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35758
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