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Tsc1 ablation in Prx1 and Osterix lineages causes renal cystogenesis in mouse

Tuberous Sclerosis Complex (TSC) is caused by mutations in TSC1 or TSC2, which encode negative regulators of the mTOR signaling pathway. The renal abnormalities associated with TSC include angiomyolipoma, cysts, and renal cell carcinoma. Here we report that specific ablation of Tsc1 using the mesenc...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Wu, Zhixiang, Wu, Hongguang, Md, Shafiquzzaman, Yu, Guo, Habib, Samy L., Li, Baojie, Li, Jing
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351533/
https://ncbi.nlm.nih.gov/pubmed/30696882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37139-9
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