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Site-1 protease ablation in the osterix-lineage in mice results in bone marrow neutrophilia and hematopoietic stem cell alterations

Site-1 protease (S1P) ablation in the osterix-lineage in mice drastically reduces bone development and downregulates bone marrow-derived skeletal stem cells. Here we show that these mice also suffer from spina bifida occulta with a characteristic lack of bone fusion in the posterior neural arches. M...

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Podrobná bibliografie
Vydáno v:Biol Open
Hlavní autoři: Patra, Debabrata, Kim, Joongho, Zhang, Qiang, Tycksen, Eric, Sandell, Linda J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328000/
https://ncbi.nlm.nih.gov/pubmed/32576566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.052993
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