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Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches

mRNA therapeutics hold great promise for the treatment of human diseases. While incorporating naturally occurring modified nucleotides during synthesis has greatly increased their potency and safety, challenges in selective expression have hindered clinical applications. MicroRNA (miRNA)-regulated i...

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Dettagli Bibliografici
Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Lockhart, John, Canfield, John, Mong, Ezinne Francess, VanWye, Jeffrey, Totary-Jain, Hana
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350232/
https://ncbi.nlm.nih.gov/pubmed/30665183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.12.007
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