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Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches

mRNA therapeutics hold great promise for the treatment of human diseases. While incorporating naturally occurring modified nucleotides during synthesis has greatly increased their potency and safety, challenges in selective expression have hindered clinical applications. MicroRNA (miRNA)-regulated i...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Ther Nucleic Acids
Egile Nagusiak: Lockhart, John, Canfield, John, Mong, Ezinne Francess, VanWye, Jeffrey, Totary-Jain, Hana
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Gene & Cell Therapy 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350232/
https://ncbi.nlm.nih.gov/pubmed/30665183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.12.007
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