Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a PI3K/Akt signaling‐dependent manner

Fibroblast growth factor 21 (FGF21) is important in glucose, lipid homeostasis and insulin sensitivity. However, it remains unknown whether FGF21 is involved in insulin expression and secretion that are dysregulated in type 2 diabetes mellitus (T2DM). In this study, we found that FGF21 was down‐regu...

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Bibliografiske detaljer
Udgivet i:J Cell Mol Med
Main Authors: Pan, Yingying, Wang, Baile, Zheng, Jujia, Xiong, Rongrong, Fan, Zhichao, Ye, Yanna, Zhang, Saisai, Li, Qinyao, Gong, Fanghua, Wu, Chaoming, Lin, Zhuofeng, Li, Xiaokun, Pan, Xuebo
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349243/
https://ncbi.nlm.nih.gov/pubmed/30461198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14007
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