Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass

Unfractionated heparin (UFH), the standard anticoagulant for cardiopulmonary bypass (CPB) surgery, carries a risk of post-operative bleeding and is potentially harmful in patients with heparin-induced thrombocytopenia-associated antibodies. To improve the activity of an alternative anticoagulant, th...

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Vydáno v:Nat Biotechnol
Hlavní autoři: Gunaratne, Ruwan, Kumar, Shekhar, Frederiksen, James W., Stayrook, Steven, Lohrmann, Jens L., Perry, Kay, Bompiani, Kristin M., Chabata, Charlene V., Thalji, Nabil K., Ho, Michelle D., Arepally, Gowthami, Camire, Rodney M., Krishnaswamy, Sriram, Sullenger, Bruce A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349032/
https://ncbi.nlm.nih.gov/pubmed/29863725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4153
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