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Probing the coagulation pathway with aptamers identifies combinations that synergistically inhibit blood clot formation
Coordinated enzymatic reactions regulate blood clot generation. To explore the contributions of various coagulation enzymes in this process, we utilized a panel of aptamers against factors VIIa, IXa, Xa, and prothrombin. Each aptamer dose-dependently inhibited clot formation, yet none was able to co...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4134678/ https://ncbi.nlm.nih.gov/pubmed/25065530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.05.016 |
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