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Association of Pharmacokinetic Profiles of Lenalidomide in Human Plasma Simulated using Pharmacokinetic Data in Humanized-liver Mice with Liver Toxicity Detected by Human Serum Albumin RNA
Lenalidomide has been shown to be potentially teratogenic in thalidomide-sensitive animal species. Screening for thalidomide analogs devoid of teratogenicity/toxicity—attributable to drug metabolism and disposition, but having immunomodulatory properties—is a strategic pathway towards development of...
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| Publicado no: | J Toxicol Sci |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6348384/ https://ncbi.nlm.nih.gov/pubmed/29877213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2131/jts.43.369 |
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