Association of Pharmacokinetic Profiles of Lenalidomide in Human Plasma Simulated using Pharmacokinetic Data in Humanized-liver Mice with Liver Toxicity Detected by Human Serum Albumin RNA

Lenalidomide has been shown to be potentially teratogenic in thalidomide-sensitive animal species. Screening for thalidomide analogs devoid of teratogenicity/toxicity—attributable to drug metabolism and disposition, but having immunomodulatory properties—is a strategic pathway towards development of...

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Veröffentlicht in:J Toxicol Sci
Hauptverfasser: Murayama, Norie, Suemizu, Hiroshi, Uehara, Shotaro, Kusama, Takashi, Mitsui, Marina, Kamiya, Yusuke, Shimizu, Makiko, Guengerich, F. Peter, Yamazaki, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348384/
https://ncbi.nlm.nih.gov/pubmed/29877213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2131/jts.43.369
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