5‐Oxyacetic Acid Modification Destabilizes Double Helical Stem Structures and Favors Anionic Watson–Crick like cmo(5)U‐G Base Pairs

Watson–Crick like G‐U mismatches with tautomeric G(enol) or U(enol) bases can evade fidelity checkpoints and thereby contribute to translational errors. The 5‐oxyacetic acid uridine (cmo(5)U) modification is a base modification at the wobble position on tRNAs and is presumed to expand the decoding c...

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Detalles Bibliográficos
Publicado en:Chemistry
Main Authors: Strebitzer, Elisabeth, Rangadurai, Atul, Plangger, Raphael, Kremser, Johannes, Juen, Michael Andreas, Tollinger, Martin, Al‐Hashimi, Hashim M., Kreutz, Christoph
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
Assuntos:
Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348377/
https://ncbi.nlm.nih.gov/pubmed/30300940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201805077
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