Emricasan, a pan caspase inhibitor, improves survival and portal hypertension in a murine model of common bile-duct ligation

Development of portal hypertension (PHT) is a central prognostic factor in patients with cirrhosis. Circulating microparticles (MPs) are released by hepatocytes in a caspase dependent manner, are increased in circulation of patients with cirrhosis and contribute to PHT via induction of impaired vaso...

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Detalhes bibliográficos
Publicado no:J Mol Med (Berl)
Main Authors: Eguchi, Akiko, Koyama, Yukinori, Wree, Alexander, Johnson, Casey D., Nakamura, Ryota, Povero, Davide, Kneiber, David, Tameda, Masahiko, Contreras, Patricia, Spada, Al, Feldstein, Ariel E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347405/
https://ncbi.nlm.nih.gov/pubmed/29728708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-018-1642-9
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