Emricasan (IDN‐6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension

Caspases play a central role in apoptosis, inflammation, and fibrosis. They produce hemodynamically active, proinflammatory microparticles that cause intrahepatic inflammation, vasoconstriction, and extrahepatic splanchnic vasodilation. Emricasan is a pan‐caspase inhibitor that lowers portal hyperte...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Garcia‐Tsao, Guadalupe, Fuchs, Michael, Shiffman, Mitchell, Borg, Brian B., Pyrsopoulos, Nikolaos, Shetty, Kirti, Gallegos‐Orozco, Juan F., Reddy, K. Rajender, Feyssa, Eyob, Chan, Jean L., Yamashita, Mason, Robinson, James M., Spada, Alfred P., Hagerty, David T., Bosch, Jaime
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587783/
https://ncbi.nlm.nih.gov/pubmed/30063802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30199
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