Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol

A potential CYP4B1 suicide gene application in engineered T-cell treatment of blood cancers has revived interest in the use of 4-ipomeanol (IPO) in gene-directed enzyme prodrug therapy, in which disposition of the administered compound may be critical. IPO contains one chiral center at the carbon be...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Teitelbaum, Aaron M., McDonald, Matthew G., Kowalski, John P., Parkinson, Oliver T., Scian, Michele, Whittington, Dale, Roellecke, Katharina, Hanenberg, Helmut, Wiek, Constanze, Rettie, Allan E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
Assuntos:
Metabolism, Transport, and Pharmacogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6346377/
https://ncbi.nlm.nih.gov/pubmed/30409834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.249771
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