Heterologous Expression and Functional Characterization of Novel CYP2C9 Variants Identified in the Alaska Native People

CYP2C9 is a major form of human liver cytochrome P450 that is responsible for the oxidative metabolism of several widely used low–therapeutic index drugs, including (S)-warfarin and phenytoin. In a cohort of Alaska Native people, ultrarare or novel CYP2C9 protein variants, M1L (rs114071557), N218I (...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: McDonald, Matthew G., Henderson, Lindsay M., Ray, Sutapa, Yeung, Catherine K., Johnson, Amanda L., Kowalski, John P., Hanenberg, Helmut, Wiek, Constanze, Thummel, Kenneth E., Rettie, Allan E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2020
Assuntos:
Metabolism, Transport, and Pharmacogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366286/
https://ncbi.nlm.nih.gov/pubmed/32423989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.265850
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