Ligand characterization of CYP4B1 isoforms modified for high-level expression in Escherichia coli and HepG2 cells

Human CYP4B1, a cytochrome P450 monooxygenase predominantly expressed in the lung, inefficiently metabolizes classical CYP4B1 substrates, such as the naturally occurring furan pro-toxin 4-ipomeanol (4-IPO). Highly active animal forms of the enzyme convert 4-IPO to reactive alkylating metabolite(s) t...

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Publicado en:Protein Eng Des Sel
Autores principales: Roellecke, Katharina, Jäger, Vera D., Gyurov, Veselin H., Kowalski, John P., Mielke, Stephanie, Rettie, Allan E., Hanenberg, Helmut, Wiek, Constanze, Girhard, Marco
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421619/
https://ncbi.nlm.nih.gov/pubmed/28073960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzw075
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