Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity

4-Ipomeanol (IPO) is a model pulmonary toxicant that undergoes P450-mediated metabolism to reactive electrophilic intermediates that bind to tissue macromolecules and can be trapped in vitro as the NAC/NAL adduct. Pronounced species and tissue differences in IPO toxicity are well documented, as is t...

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Udgivet i:Drug Metab Dispos
Main Authors: Parkinson, Oliver T., Teitelbaum, Aaron M., Whittington, Dale, Kelly, Edward J., Rettie, Allan E.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2016
Fag:
Short Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034698/
https://ncbi.nlm.nih.gov/pubmed/27468999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.070003
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