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The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma
Cholangiocarcinoma (CCA) is an aggressive cancer with high resistance to chemotherapeutics. CCA is enriched in cancer stem cells, which correlate with aggressiveness and prognosis. FXR, a member of the metabolic nuclear receptor family, is markedly down-regulated in human CCA. Our aim was to evaluat...
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| Publicado no: | PLoS One |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6345424/ https://ncbi.nlm.nih.gov/pubmed/30677052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0210077 |
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