Metformin exerts anti-cancerogenic effects and reverses epithelial-to-mesenchymal transition trait in primary human intrahepatic cholangiocarcinoma cells

Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer with marked resistance to chemotherapeutics without therapies. The tumour microenvironment of iCCA is enriched of Cancer-Stem-Cells expressing Epithelial-to-Mesenchymal Transition (EMT) traits, being these features associated with...

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Wydane w:Sci Rep
Główni autorzy: Di Matteo, Sabina, Nevi, Lorenzo, Overi, Diletta, Landolina, Nadine, Faccioli, Jessica, Giulitti, Federico, Napoletano, Chiara, Oddi, Andrea, Marziani, Augusto M., Costantini, Daniele, De Rose, Agostino M., Melandro, Fabio, Bragazzi, Maria C., Grazi, Gian Luca, Berloco, Pasquale B., Giuliante, Felice, Donato, Giuseppe, Moretta, Lorenzo, Carpino, Guido, Cardinale, Vincenzo, Gaudio, Eugenio, Alvaro, Domenico
Format: Artigo
Język:Inglês
Wydane: Nature Publishing Group UK 2021
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844056/
https://ncbi.nlm.nih.gov/pubmed/33510179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81172-0
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