Simulated microgravity promotes the formation of tridimensional cultures and stimulates pluripotency and a glycolytic metabolism in human hepatic and biliary tree stem/progenitor cells

Many pivotal biological cell processes are affected by gravity. The aim of our study was to evaluate biological and functional effects, differentiation potential and exo-metabolome profile of simulated microgravity (SMG) on human hepatic cell line (HepG2) and human biliary tree stem/progenitor cells...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Costantini, Daniele, Overi, Diletta, Casadei, Luca, Cardinale, Vincenzo, Nevi, Lorenzo, Carpino, Guido, Di Matteo, Sabina, Safarikia, Samira, Valerio, Mariacristina, Melandro, Fabio, Bizzarri, Mariano, Manetti, Cesare, Berloco, Pasquale Bartolomeo, Gaudio, Eugenio, Alvaro, Domenico
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447605/
https://ncbi.nlm.nih.gov/pubmed/30944365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41908-5
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