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Multiheterocyclic Motifs via Three-Component Reactions of Benzynes, Cyclic Amines, and Protic–Nucleophiles
A broadly general, three-component reaction strategy for the construction of compounds containing multiple heterocycles is described. Thermal benzyne formation (by the hexadehydro-Diels–Alder (HDDA) reaction) in the presence of tertiary cyclic amines and a protic nucleophile (HNu) gives, via ring-op...
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| Publicado no: | Org Lett |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6344887/ https://ncbi.nlm.nih.gov/pubmed/29239617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b03458 |
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