Excision of uracil from DNA by hSMUG1 includes strand incision and processing

Uracil arises in DNA by hydrolytic deamination of cytosine (C) and by erroneous incorporation of deoxyuridine monophosphate opposite adenine, where the former event is devastating by generation of C → thymine transitions. The base excision repair (BER) pathway replaces uracil by the correct base. In...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Alexeeva, Marina, Moen, Marivi N, Grøsvik, Kristin, Tesfahun, Almaz N, Xu, Xiang Ming, Muruzábal-Lecumberri, Izaskun, Olsen, Kristine M, Rasmussen, Anette, Ruoff, Peter, Kirpekar, Finn, Klungland, Arne, Bjelland, Svein
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344882/
https://ncbi.nlm.nih.gov/pubmed/30496516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1184
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