Metabolomics and proteomics identify the toxic form and the associated cellular binding targets of the anti-proliferative drug AICAR

5-Aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR, or acadesine) is a precursor of the monophosphate derivative 5-amino-4-imidazole carboxamide ribonucleoside 5′-phosphate (ZMP), an intermediate in de novo purine biosynthesis. AICAR proved to have promising anti-proliferative properties, al...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Douillet, Delphine C., Pinson, Benoît, Ceschin, Johanna, Hürlimann, Hans C., Saint-Marc, Christelle, Laporte, Damien, Claverol, Stéphane, Konrad, Manfred, Bonneu, Marc, Daignan-Fornier, Bertrand
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6341394/
https://ncbi.nlm.nih.gov/pubmed/30478173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004964
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