Identification of Yeast and Human 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) Transporters

5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) is the precursor of the active monophosphate form (AICAR), a small molecule with potent anti-proliferative and low energy mimetic properties. The molecular bases for AICAR toxicity at the cellular level are poorly understood. Here, we repor...

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Dettagli Bibliografici
Autori principali: Ceschin, Johanna, Saint-Marc, Christelle, Laporte, Jean, Labriet, Adrien, Philippe, Chloé, Moenner, Michel, Daignan-Fornier, Bertrand, Pinson, Benoît
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059127/
https://ncbi.nlm.nih.gov/pubmed/24778186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.551192
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