Disruption of Nucleotide Homeostasis by the Antiproliferative Drug 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside Monophosphate (AICAR)

5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside monophosphate (AICAR) is a natural metabolite with potent anti-proliferative and low energy mimetic properties. At high concentration, AICAR is toxic for yeast and mammalian cells, but the molecular basis of this toxicity is poorly understood. Here...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ceschin, Johanna, Hürlimann, Hans Caspar, Saint-Marc, Christelle, Albrecht, Delphine, Violo, Typhaine, Moenner, Michel, Daignan-Fornier, Bertrand, Pinson, Benoît
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583016/
https://ncbi.nlm.nih.gov/pubmed/26283791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656017
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