Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and Humans

Identifying synthetic lethal interactions has emerged as a promising new therapeutic approach aimed at targeting cancer cells directly. Here, we used the yeast Saccharomyces cerevisiae as a simple eukaryotic model to screen for mutations resulting in a synthetic lethality with 5-amino-4-imidazole ca...

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Bibliografische gegevens
Gepubliceerd in:Genetics
Hoofdauteurs: Albrecht, Delphine, Ceschin, Johanna, Dompierre, Jim, Gueniot, Florian, Pinson, Benoît, Daignan-Fornier, Bertrand
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Genetics Society of America 2016
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Investigations
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161278/
https://ncbi.nlm.nih.gov/pubmed/27707786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.192518
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