Physiological and Toxic Effects of Purine Intermediate 5-Amino-4-imidazolecarboxamide Ribonucleotide (AICAR) in Yeast

5-Amino-4-imidazolecarboxamide ribonucleotide 5′-phosphate (AICAR) is a monophosphate metabolic intermediate of the de novo purine synthesis pathway that has highly promising metabolic and antiproliferative properties. Yeast mutants unable to metabolize AICAR are auxotroph for histidine. A screening...

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Main Authors: Hürlimann, Hans C., Laloo, Benoît, Simon-Kayser, Barbara, Saint-Marc, Christelle, Coulpier, Fanny, Lemoine, Sophie, Daignan-Fornier, Bertrand, Pinson, Benoît
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Gene Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162458/
https://ncbi.nlm.nih.gov/pubmed/21757731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.262659
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