Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways

Cells use strategic metabolites to sense the metabolome and accordingly modulate gene expression. Here, we show that the purine and phosphate pathways are positively regulated by the metabolic intermediate AICAR (5′-phosphoribosyl-5-amino-4-imidazole carboxamide). The transcription factor Pho2p is r...

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Bibliografiska uppgifter
Huvudupphovsmän: Pinson, Benoît, Vaur, Sabine, Sagot, Isabelle, Coulpier, Fanny, Lemoine, Sophie, Daignan-Fornier, Bertrand
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2009
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701576/
https://ncbi.nlm.nih.gov/pubmed/19528318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.521809
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