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Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways
Cells use strategic metabolites to sense the metabolome and accordingly modulate gene expression. Here, we show that the purine and phosphate pathways are positively regulated by the metabolic intermediate AICAR (5′-phosphoribosyl-5-amino-4-imidazole carboxamide). The transcription factor Pho2p is r...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701576/ https://ncbi.nlm.nih.gov/pubmed/19528318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.521809 |
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