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Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways
Cells use strategic metabolites to sense the metabolome and accordingly modulate gene expression. Here, we show that the purine and phosphate pathways are positively regulated by the metabolic intermediate AICAR (5′-phosphoribosyl-5-amino-4-imidazole carboxamide). The transcription factor Pho2p is r...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701576/ https://ncbi.nlm.nih.gov/pubmed/19528318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.521809 |
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