Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways

Cells use strategic metabolites to sense the metabolome and accordingly modulate gene expression. Here, we show that the purine and phosphate pathways are positively regulated by the metabolic intermediate AICAR (5′-phosphoribosyl-5-amino-4-imidazole carboxamide). The transcription factor Pho2p is r...

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Bibliografiske detaljer
Main Authors: Pinson, Benoît, Vaur, Sabine, Sagot, Isabelle, Coulpier, Fanny, Lemoine, Sophie, Daignan-Fornier, Bertrand
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2009
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701576/
https://ncbi.nlm.nih.gov/pubmed/19528318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.521809
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