Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states

AMP-activated protein kinase (AMPK) is an attractive therapeutic target for managing metabolic diseases. A class of pharmacological activators, including Merck 991, binds the AMPK ADaM site, which forms the interaction surface between the kinase domain (KD) of the α-subunit and the carbohydrate-bind...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Yan, Yan, Zhou, X. Edward, Novick, Scott J., Shaw, Simon J., Li, Yingwu, Brunzelle, Joseph S., Hitoshi, Yasumichi, Griffin, Patrick R., Xu, H. Eric, Melcher, Karsten
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2019
Onderwerpen:
Signal Transduction
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6341387/
https://ncbi.nlm.nih.gov/pubmed/30478170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004883
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items