Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states

AMP-activated protein kinase (AMPK) is an attractive therapeutic target for managing metabolic diseases. A class of pharmacological activators, including Merck 991, binds the AMPK ADaM site, which forms the interaction surface between the kinase domain (KD) of the α-subunit and the carbohydrate-bind...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yan, Yan, Zhou, X. Edward, Novick, Scott J., Shaw, Simon J., Li, Yingwu, Brunzelle, Joseph S., Hitoshi, Yasumichi, Griffin, Patrick R., Xu, H. Eric, Melcher, Karsten
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6341387/
https://ncbi.nlm.nih.gov/pubmed/30478170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004883
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